Volume No. 18
2022
Pages 1 - 1771
Table of Contents |
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| 124 | Full Research Paper |
| 17 | Review |
| 31 | Letter |
| 5 | Perspective |
| 1 | Commentary |
| 7 | Editorial |
- Full Research Paper
- Published 31 May 2022
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Figure 1: Biologically active cholic acid hybridized with different heterocyclic scaffolds.
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Scheme 1: Synthesis of cholyl 1,3,4-oxadiazole-2-thiol 2.
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Scheme 2: Synthesis of cholyl 2-(propargylthio)-1,3,4-oxadiazole 3.
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Scheme 3: Synthesis of target compounds 4a–v.
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Figure 2: Structures of target compounds 4a–v.
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- Published 01 Jun 2022
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Figure 1: Our work on mechanochemical C–N coupling reactions using DDQ. The newly formed C–N bonds are shown ...
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Figure 2: Scope of the mechanochemical synthesis of substituted benzimidazoles.
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Figure 3: Synthesis of quinazolin-4(3H)-one derivatives.
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Figure 4: The substrate scope for the synthesis of quinazolin-4(3H)-one derivatives.
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Figure 5: a) Control experiment and b) Plausible mechanism.
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Figure 6: Large-scale synthesis. a) 1,2-Disubstituted benzimidazoles. b) Substituted quinazolin-4(3H)-ones. R...
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- Letter
- Published 03 Jun 2022
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Scheme 1: Amination of arenes with phthalimides.
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Scheme 2: Substrate scope of the copper-catalyzed C–H imidation of arenes. Reaction conditions: 1 (2.0 mL as ...
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Scheme 3: Substrate scope of the copper-catalyzed C–H imidation of N-hydroxyphthalimide. Reaction conditions: ...
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Scheme 4: A plausible reaction mechanism.
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- Published 10 Jun 2022
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Figure 1: Structure of lumateperone.
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Scheme 1: First synthetic route leading to lumateperone (1).
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Scheme 2: Alternate synthesis of lumateperone.
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Scheme 3: Alternate synthetic approaches leading to racemic lumateperone ((±)-1)).
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Scheme 4: Planned new synthesis of key intermediate (±)-9a.
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Scheme 5: New synthesis of key intermediate (±)-9a.
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Scheme 6: Trifluoroacetylation of tetrahydroquinoxaline (37).
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- Letter
- Published 13 Jun 2022
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Scheme 1: Synthesis of cyclochexene oxide via epoxidation with air in the presence of isobutyraldehyde.
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Figure 1: Epoxidation of cyclohexene with air bubbling in batch at various temperature.
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Figure 2: Schematic diagram (a) and photo (b) of the flow reactor used for cyclohexene epoxidation with air. ...
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Figure 3: Investigation of reaction temperature in flow epoxidation of cyclohexene at residence time of 0.35 ...
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Figure 4: Investigation of residence time in flow epoxidation of cyclohexene at 100 °C.
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Scheme 2: Plausible reaction pathway of the epoxidation of cyclohexene with air in the flow system.
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Figure 5: Continuous production of cyclohexene oxide.
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Figure 6: Effect of concentration of cyclohexene and eqivalent of aldehyde.
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- Published 14 Jun 2022
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Figure 1: Single crystal structure of compound 3l.
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Figure 2: Single crystal structure of compound 3s.
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Figure 3: Single crystal structure of compound 3f’.
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Figure 4: Single crystal structure of compound 5a.
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Scheme 1: Proposed reaction mechanism for the compounds 3 and 5.
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Figure 5: Single crystal struture of compound 8a.
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Scheme 2: Proposed mechanism for the formation of dispiro compounds 8.
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- Published 15 Jun 2022
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Figure 1: Molecular structures of the monomeric cyclopalladated intermediate and brominated product observed ...
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Scheme 1: Halogenation of azobenzenes with strong electron-donating substituents.
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Figure 2: a) Two-dimensional (2D) plot of the time-resolved Raman monitoring of NG of L2 (0.50 mmol) with NBS...
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Figure 3: Experimental X-ray molecular structure of succinimide product L4-III.
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Scheme 2: PdII-catalyzed halogenation of azobenzene and its para-halogenated derivatives.
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Figure 4: Experimental X-ray molecular structure of the intermediate I6-I.
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Figure 5: a) In situ observation of I6-I during the time-resolved Raman monitoring of LAG of L6 (0.50 mmol) w...
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- Review
- Published 20 Jun 2022
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Figure 1: Inductive heating, a powerful tool in industry and the Life Sciences.
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Figure 2: Electric displacement field of a ferromagnetic and superparamagnetic material.
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Figure 3: Temperature profiles of reactors heated conventionally and by RF heating (Figure 3 redrawn from [24]).
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Scheme 1: Continuous flow synthesis of isopulegol (2) from citronellal (1).
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Scheme 2: Dry (reaction 1) and steam (reaction 2) methane reforming.
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Scheme 3: Calcination and RF heating.
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Scheme 4: The continuously operated “Sabatier” process.
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Scheme 5: Biofuel production from biomass using inductive heating for pyrolysis.
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Scheme 6: Water electrolysis using an inductively heated electrolysis cell.
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Scheme 7: Dimroth rearrangement (reaction 1) and three-component reaction (reaction 2) to propargyl amines 8 ...
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Figure 4: A. Flow reactor filled with magnetic nanostructured particles (MagSilicaTM) and packed bed reactor ...
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Scheme 8: Claisen rearrangement in flow: A. comparison between conventional heating (external oil bath), micr...
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Scheme 9: Continuous flow reactions and comparison with batch reaction (oil bath). A. Pd-catalyzed transfer h...
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Scheme 10: Continuous flow reactions and comparison with batch reaction (oil bath). A. pericyclic reactions an...
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Scheme 11: Reactions under flow conditions using inductively heated fixed-bed materials serving as stoichiomet...
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Scheme 12: Reactions under flow conditions using inductively heated fixed-bed materials serving as catalysts: ...
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Scheme 13: Two step flow protocol for the preparation of 1,1'-diarylalkanes 77 from ketones and aldehydes 74, ...
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Scheme 14: O-Alkylation, the last step in the multistep flow synthesis of Iloperidone (80) accompanied with a ...
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Scheme 15: Continuous two-step flow process consisting of Grignard reaction followed by water elimination bein...
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Scheme 16: Inductively heated continuous flow protocol for the synthesis of Iso E Super (88) [91,92].
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Scheme 17: Three-step continuous flow synthesis of macrocycles 89 and 90 with musk-like olfactoric properties.
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- Review
- Published 21 Jun 2022
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Figure 1: Examples of endoperoxide-containing natural products.
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Scheme 1: Reactions of COXs.
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Figure 2: Structures of COXs [52,53]. (A) The overall structure of ovine COX-1. (B and C) Comparison of the cyclooxy...
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Scheme 2: Proposed reaction mechanisms of COXs [24].
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Scheme 3: General reaction mechanism of Fe/2OG oxygenases.
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Scheme 4: Reaction of FtmOx1 [68-71].
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Figure 3: Structure of FtmOx1 [71]. (A) The FtmOx1 binary structure in complex with 2OG. (B and C) Comparison of ...
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Scheme 5: Proposed COX-like mechanism of FtmOx1 [68].
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Scheme 6: Proposed CarC-like mechanism of FtmOx1 [70].
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Scheme 7: Reaction of NvfI [28].
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Scheme 8: Possible reaction pathways leading to fumigatonoid A [28].
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Figure 4: Structure of NvfI [28]. (A–C) Conformational changes of loop regions: (A) open conformation, (B) partia...
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Scheme 9: Another possible reaction pathway for the formation of fumigatonoid A [28].
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- Full Research Paper
- Published 22 Jun 2022
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Figure 1: Prenylated aromatic metabolites are involved in cellular processes like cell respiration (coenzyme Q...
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Figure 2: Homology clustering of Ptases encoded in marine Flavobacteria and Saccharomonospora species (G1–G4,...
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Figure 3: Regional alignment of ubiA-297 of Maribacter sp. MS6 (EU359911.1) and homologous genes in Z. uligin...
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Figure 4: A) Amino acid alignment and binding residues of UbiA-297. G2-Ptases are illustrated in the grey box...
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Figure 5: Evaluation of substrate specificity of UbiA-297. Accepted substrates are shown in red, while no pro...
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Figure 6: A) Reaction scheme of UbiA-297 catalyzing the assumed para-directed farnesylation of 8-HQA; B) calc...
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- Published 22 Jun 2022
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Scheme 1: Historic synthetic approaches.
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Figure 1: Resonance forms of isocyanides.
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Scheme 2: Comparison between the previous mechanochemical synthetic pathway [24] and the new adapted one in this ...
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Scheme 3: The scope of our isocyanide synthesis using aliphatic and aromatic primary formamides. Reaction con...
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Figure 2: The purification process of a brownish isocyanide on a short silica pad.
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Scheme 4: Suggested proton transfer mechanism.
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- Published 23 Jun 2022
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Scheme 1: Approaches to the synthesis of alkyl 4-oxo-1,4-dihydropyridine-3-carboxylates.
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Scheme 2: Synthesis of 4-oxo-1,4-dihydropyridine-3-carboxylates.
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Scheme 3: Synthesis of Isoxazoles 11–13.
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Scheme 4: Synthesis of isoxazoles 1.
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Scheme 5: Synthesis of pyridones 2.
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Scheme 6: Transformations of pyridones 2.
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- Published 24 Jun 2022
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Figure 1: Highly reactive dienophiles.
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Figure 2: Dibromide substrates and product 12.
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Scheme 1: Mechanochemical reaction of 10 with anthracene.
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Figure 3: Scope of the Zn/Cu reaction with dibromide 10 (dienes are colored in red).
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Scheme 2: Mechanochemical reaction of 11 with furan.
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Scheme 3: Reactivity of bicyclo[2.2.2] dibromide 42 with dienes.
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- Review
- Published 27 Jun 2022
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Figure 1: The olfactory spectrum wheel ordering different types of odorants from fruity to musky.
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Figure 2: Classification of odorants as “top note”, “middle note” and “base note” depending on their substant...
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Scheme 1: Synthesis of raspberry ketone (5) and raspberry ketone methyl ether (6) in two steps in flow.
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Scheme 2: Autoxidation of (+)-valencene (7) to (+)-nootkatone (8) under catalyst and solvent-free conditions ...
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Scheme 3: Enzyme-catalyzed acetylation of isoamyl alcohol (9) in a biphasic n-heptane/water mixture utilizing...
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Scheme 4: Esterification of alcohols by transesterification, catalyzed by immobilized acyltransferase in a pa...
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Scheme 5: Synthesis of homologated alcohols 20 by iterative homologation of terpenyl boronate esters 17 follo...
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Scheme 6: Sequential three-step synthesis of (S)-α-phellandrene (30) from (R)-carvone (25) via selective hydr...
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Scheme 7: Selective hydrogenation of alkyne 31 to “leaf alcohol” 32 employing a solid-supported palladium cat...
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Scheme 8: A) Synthesis of jasmonal (35) by crossed aldol condensation of benzaldehyde (33) and heptanal (34) ...
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Scheme 9: Synthesis of thymol (41) from m-cresol (39) and isopropyl alcohol via Fries-type rearrangement of e...
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Scheme 10: Preparation of coumarin (46) by reaction of salicylaldehyde (44) with potassium acetate, acetic aci...
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Scheme 11: Synthesis of phthalide (50) by photoinduced decatungstate catalysis.
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Scheme 12: Synthesis of woody acetate (54) by reduction of cyclohexanone 51 and subsequent acetylation; ADH200...
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Scheme 13: Synthesis of juniper lactone (56) by pyrolysis of triperoxide 55 generated by oxidation of cyclohex...
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Scheme 14: Synthesis of macrocyclic olefine 60 by ring-closing metathesis of diene 58 in a continuously stirre...
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Scheme 15: Synthesis of macrocycles 65 and 66 by ring-closing metathesis of dienes 62 or 63, respectively, in ...
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Scheme 16: Z-Selective synthesis of civetone (69) enabled by metathesis catalyst 68 in a tube-in-tube reactor.
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Scheme 17: Synthesis of macrocyclic olefine 72 by ring-closing metathesis of diene 70.
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- Full Research Paper
- Published 29 Jun 2022
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Scheme 1: Early studies concerning cyclopropene cycloadditions to azomethine ylides and cycloaddition reactio...
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Scheme 2: The pilot experiment aimed at studying the cycloaddition reaction between the protonated form of Ru...
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Scheme 3: Synthesis of meso-3'-azadispiro[indene-2,2'-bicyclo[3.1.0]hexane-4',2''-indene] derivatives 3b–g vi...
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Figure 1: ORTEP representation of the molecular structure of 3e.
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Scheme 4: The reaction of protonated Ruhemann's purple (1) with 3-methyl-3-phenylcyclopropene (2j).
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Scheme 5: Attempts to carry out the cycloaddition reactions between 3,3-disubstituted cyclopropenes 2k,l and ...
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Scheme 6: The reactions of protonated Ruhemann's purple (1) with unstable cyclopropenes 2m–p.
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Scheme 7: The acid–base reaction of Ruhemann's purple with hydrochloric acid and relative Gibbs free energy c...
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Scheme 8: Plausible mechanism of the 1,3-DC reaction of protonated Ruhemann's purple (1) with 3-methyl-3-phen...
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Scheme 9: Plausible mechanism of the 1,3-DC reaction of protonated Ruhemann's purple (1) with 1-chloro-2-phen...
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- Published 30 Jun 2022
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Scheme 1: Baeyer–Mills reaction of AB (1a) involving nucleophilic attack of aniline (2a) to nitrosobenzene (3...
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Figure 1: Flow setup for optimization of the Baeyer–Mills reaction with aniline (2a) and nitrosobenzene (3). ...
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Figure 2: Optimization of the Baeyer–Mills reaction of nitrosobenzene (3) with aniline (2a) to AB (1a). The n...
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Figure 3: Flow setup after prior optimization with unsubstituted aniline (2a) and nitrosobenzene (3) to AB (1a...
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Scheme 2: Large-scale synthesis of AB 1t from aniline 2t and nitrosobenzene (3) in >99% yield within 3 days.
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- Published 04 Jul 2022
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Scheme 1: Envisioned Minisci perfluoroalkylation facilitated by “dummy group” reagents 1a–c.
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Scheme 2: Control experiments for the nucleophilic substitution of perfluoroalkylsulfinates 2 and halogenated...
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Scheme 3: Left: isolated yields of synthesized perfluoroalkylating reagents: perfluorobutyl (1a), perfluorohe...
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Scheme 4: Radical trapping experiment with 1,1-diphenylethylene (7) and 1b confirming the initially proposed ...
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Scheme 5: Demonstrative scope for the perfluoroalkylation of aromatics. Isolated yields are shown in parenthe...
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- Published 07 Jul 2022
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Scheme 1: Construction of diverse tetrahydrocarbazoles via Levy-type reaction.
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Scheme 2: Synthesis of spiro[carbazole-3,3'-inolines]. Reaction conditions: 2-methylindole (0.5 mmol), aromat...
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Scheme 3: Synthesis of spiro[carbazole-2,3'-indolines]. Reaction conditions: 2-methylindole (0.5 mmol), aroma...
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Scheme 4: Synthesis of tetrahydrospiro[carbazole-3,5'-pyrimidines]. Reaction conditions: 2-methylindole (0.5 ...
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Scheme 5: Synthesis of tetrahydrospiro[carbazole-3,1'-cycloalkane]-diones. Reaction conditions: 2-methylindol...
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Scheme 6: Synthesis of 3,3'-(arylmethylene)bis(2-methyl-1H-indole). Reaction conditions: 2-methylindole (1.0 ...
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Scheme 7: Proposed reaction mechanism for the multicomponent reaction.
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- Letter
- Published 08 Jul 2022
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Figure 1: Molecular structures of bull horn-shaped heteroacene 1, selenophene-based [7]helicene 2 and novel c...
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Scheme 1: Synthetic route to S-shaped double helicenes DH-1–3.
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Figure 2: Five kinds of isomer structures of 5 and two kinds of possible oxidative photocyclization product s...
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Figure 3: Molecular structures and side view for DH-1 and DH-2. A and B are molecular structures for DH-1 and ...
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Figure 4: UV–vis absorption spectra of DH-1–3 in CH2Cl2 ([c] = 1 × 10−5 M).
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- Published 08 Jul 2022
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Scheme 1: Biosynthesis of 2-MIB (1). A) Naturally observed pathway through methylation of GPP to 2-Me-GPP by ...
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Figure 1: A) Active site of 2MIBS with the bound substrate surrogate 2FGPP (generated with Pymol from the cry...
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Scheme 2: Synthesis of (R)- and (S)-2-Me-LPP.
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Figure 2: Structures of 2MIBS side products and spontaneous degradation products of 2-Me-LPP. The enantiomers...
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Figure 3: Total ion chromatograms of extracts from an incubation of A) enantiomerically pure (R)-2-Me-LPP wit...
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Scheme 3: Hypothetical mechanism for the isomerization of (S)-2-Me-LPP through 2-Me-GPP to (R)-2-Me-LPP.
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- Published 12 Jul 2022
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Figure 1: Chemical structures of Lewis acid examples.
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Figure 2: Chemical structures of Lewis basic fluorescent polymer poly{2,5-pyridylene-co-1,4-[2,5-bis(2-ethylh...
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Figure 3: (a) Normalized PL spectra of films with compound 1 doped with different Lewis acids. (b) PL spectra...
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Figure 4: Schematic diagram of a BF3·OEt2 vapor-treated device and the macroscopic gradation emissive pattern...
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Figure 5: Chemical structures of Lewis basic fluorescent compounds 3–14.
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Figure 6: (a) PL spectra of compound 6 in toluene after addition of 0.0 (black line), 0.1 (red line), 0.3 (gr...
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Figure 7: Photos of a solution of compound 12 and B(C6F5)3 at different ratios in toluene under a 365 nm UV l...
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Figure 8: Structure of small molecule 15 containing pyridine and thiazole groups reported by Bazan et al. and...
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Figure 9: (a) 1H NMR spectra in the aromatic region and (b) 19F NMR spectra of compound 15 (top) and the mixt...
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Figure 10: Pyrazine-containing polymers 19 and 20 investigated by Li et al.
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Figure 11: (a) HOMO/LUMO orbitals and energy levels (unit: eV) and (b) electrostatic potential surface (EPS) m...
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Figure 12: (a) UV–vis absorbance and (b) PL spectra (excited by 330 nm) for 35DCzPPy (compound 14), B(C6F5)3, ...
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Figure 13: (a) Schematic diagram of the low-band gap materials 21 and 22. (b) Ground state geometry optimizati...
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- Published 13 Jul 2022
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Figure 1: FDA-approved HDAC inhibitors with a hydroxamic acid moiety.
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Scheme 1: Synthesis of compounds 3–18. Reagents and conditions: (a) ethyl 2-bromoethanoate, TBAB, TEA, 50–60 ...
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Scheme 2: Synthesis of compounds 20–31. Reagents and conditions: (a) ethyl 2-bromoethanoate (for 22) (or ethy...
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Figure 2: The conformational and tautomeric forms of hydroxamic acids according to [36].
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Figure 3: Fragment of the 1H NMR spectrum in DMSO-d6 of compound 12.
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Figure 1: (A) Summary of the main side chains exerting significant steric and/or electronic effects and influ...
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Figure 2: Solution-phase synthesis of N-(methylamino)glycine oligomers using N-Boc-N-methylhydrazine as a sub...
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Scheme 1: Submonomer synthesis used for the construction of peptoids 1–5 containing N-methylamino side chains...
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Scheme 2: Evaluation of the efficiency of mixed anhydride methods by coupling of 1a and 1c.
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Scheme 3: (3 + 3) segment coupling of trimers 3-OH onto trimer hydrazine 3a.
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Figure 3: X-ray crystal structure of peptoid dimer 2: (A) single molecule; (B) unit cell, view along b axis (...
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Figure 4: NOE effect interaction observed in the 2D-NOESY spectra of monomer 1 and dimer 2 in DMSO-d6.
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Figure 5: Comparison of monomers A and B with respect to their ability to form intramolecular and intermolecu...
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Figure 6: Model structure of N-(NMe)glycine peptoid. (A) dimer in the repeating (pp) conformation; (B) dimer ...
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- Published 18 Jul 2022
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Scheme 1: Development of the first solid-state palladium-catalyzed borylation protocol of aryl halides using ...
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Scheme 2: Substrate scope of solid aryl bromides. Reaction conditions: a mixture of 1 (0.30 mmol), 2 (0.36 mm...
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Scheme 3: Substrate scope of liquid aryl bromides. Reaction conditions: a mixture of 1 (0.30 mmol), 2 (0.36 m...
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Scheme 4: Reactions of solid aryl iodide and chloride. Reaction conditions: a mixture of 1 (0.30 mmol), 2 (0....
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Scheme 5: Solid-state borylation of aryl halides on a gram scale.
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Figure 1: Biologically active selenides having alkynyl or imidazopyridinyl groups.
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Figure 2: (a) ORTEP drawing of 4aa and (b) its stacking structure.
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Scheme 1: Control reactions.
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Figure 3: Proposed mechanism.
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Scheme 2: Transformation from 4aa.
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Scheme 1: Electrochemical gem-difluorination of sulfides bearing α-electron-withdrawing groups.
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Scheme 2: Electrochemical gem-difluorodesulfurization of dithioacetals.
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Scheme 3: Electrochemical gem-difluorodesulfurization of dithiocarbonate.
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Scheme 4: Cathodic reduction of 1.
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Figure 1: Cyclic voltammograms of (a) PhSCF2Br (1, 8 mM) in 0.1 M n-Bu4NClO4/MeCN; (b) o-phthalonitrile (4 mM...
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Scheme 5: Indirect cathodic reduction of 1 using o-phthalonitrile as mediator.
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Scheme 6: Mechanism for the formation of product 3.
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Scheme 7: Reaction of compound 1 with PhS anions.
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Scheme 8: Cathodic reduction of compound 1 in the presence of α-methylstyrene at a high current density.
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Scheme 9: Indirect cathodic reduction of compound 1 in CD3CN.
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Scheme 10: Indirect cathodic reduction of compound 1 in the presence of 1,1-diphenylethylene.
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Scheme 11: Reaction mechanism.
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Figure 1: (a) The natural pathways (MVA: blue, MEP: green) for producing IPP and DMAPP; (b) the carbon skelet...
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Figure 2: Truncated artificial pathways (six steps) to produce terpentetriene and ent-kaurene.
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Figure 3: Construction maps of single plasmid expression system and two-plasmid expression system for overpro...
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Figure 4: Optimizing the ratios of ISO/DMAA for overproducing terpentetriene (a) and ent-kaurene (b). Red: IS...
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Figure 5: (a) Terpentetriene (red) and ent-kaurene (blue) yields supplied with various concentrations of glyc...
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- Published 22 Jul 2022
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Graphical Abstract
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Figure 1: Biologically active 1,2-azaphospholine 2-oxide derivatives.
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Figure 2: Diverse synthetic strategies for the preparation of 1,2-azaphospholidine and 1,2-azaphospholine 2-o...
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Scheme 1: Synthesis of 1-phenyl-2-phenylamino-γ-phosphonolactam (2) from N,N’-diphenyl 3-chloropropylphosphon...
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Scheme 2: Synthesis of 2-ethoxy-1-methyl-γ-phosphonolactam (6) from ethyl N-methyl-(3-bromopropyl)phosphonami...
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Scheme 3: Synthesis of 2-aryl-1-methyl-2,3-dihydrobenzo[c][1,2]azaphosphole 1-oxides 13 from N-aryl-2-chlorom...
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Scheme 4: Synthesis of 2,3-dihydrobenzo[c][1,2]azaphosphole 1-oxides from alkylarylphosphinyl or diarylphosph...
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Scheme 5: Synthesis of 3-arylmethylidene-2,3-dihydrobenzo[c][1,2]azaphosphole 1-oxides via the TBAF-mediated ...
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Scheme 6: Synthesis of 2-hydrobenzo[c][1,2]azaphosphol-3-one 1-oxides via the metal-free intramolecular oxida...
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Scheme 7: Synthesis of 1,3-dihydrobenzo[d][1,2]azaphosphole 2-oxides 42 and 44 from ethyl/benzyl 2-bromobenzy...
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Scheme 8: Synthesis of azaphospholidine 2-oxides/sulfide from 1,2-oxaphospholane 2-oxides/sulfides and 1,2-th...
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Scheme 9: Synthesis of 1,3-dihydrobenzo[d][1,2]azaphosphole 2-oxides/sulfides from 2-aminobenzyl(phenyl)phosp...
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Scheme 10: Synthesis of 1,3-dihydrobenzo[d][1,2]azaphosphole 2-sulfide (59) from zwitterionic 2-aminobenzyl(ph...
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Scheme 11: Synthesis of 1,3-dihydrobenzo[d][1,2]azaphosphole 2-oxides from 2-aminobenzyl(methyl/phenyl)phosphi...
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Scheme 12: Synthesis of ethyl 2-methyl-1,2-azaphospholidine-5-carboxylate 2-oxide 69 from 2-amino-4-(hydroxy(m...
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Scheme 13: Synthesis of 2-methoxy-1,3-dihydrobenzo[d][1,2]azaphosphole 2-oxide 71 from dimethyl 2-(methylamino...
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Scheme 14: Synthesis of tricyclic γ-phosphonolactams via formation of the P–C bond.
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Scheme 15: Synthesis of γ-phosphonolactams 85 from ethyl 2-(3-chloropropyl)aminoalkanoates with diethyl chloro...
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Scheme 16: Synthesis of N-phosphoryl- and N-thiophosphoryl-1,2-azaphospholidine 2-oxides 90/2-sulfides 91 from...
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Scheme 17: Synthesis of 1-methyl-1,3-dihydrobenzo[d][1,2]azaphosphole 2-oxides 56a and 93 from P-(chloromethyl...
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Scheme 18: Synthesis of 2-allylamino-1,5-dihydro-1,2-azaphosphole 2-oxides from N,N’-diallyl-vinylphosphonodia...
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Scheme 19: Diastereoselective synthesis of 2-allylamino-1,5-dihydro-1,2-azaphosphole 2-oxides from N,N’-dially...
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Scheme 20: Synthesis of 1-alkyl-3-benzoyl-2-ethoxy-1,3-dihydrobenzo[d][1,2]azaphosphole 2-oxides 106 from ethy...
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Scheme 21: Synthesis of cyclohexadiene-fused γ-phosphinolactams from diphenyl-N-benzyl-N-methylphosphinamide (...
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Scheme 22: Synthesis of cyclohexadiene-fused γ-phosphinolactams from diphenyl-N-alkyl-N-benzylphosphinamides.
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Scheme 23: Synthesis of cyclohexadiene-fused γ-phosphinolactams from diphenyl-N-methyl-N-(1-phenylethyl)phosph...
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Scheme 24: Synthesis of benzocyclohexadiene-fused γ-phosphinolactams from dinaphth-1-yl-N-alkyl-N-benzylphosph...
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Scheme 25: Synthesis of benzocyclohexadiene-fused γ-phosphinolactams from dinaphth-1-yl-N-benzyl-N-methylphosp...
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Scheme 26: Synthesis of carbonyl-containing benzocyclohexadiene-fused γ-phosphinolactams from dinaphth-1-yl-N-...
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Scheme 27: Synthesis of benzocyclohexadiene-fused γ-phosphinolactams from dinaphthyl-N-benzyl-N-methylphosphin...
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Scheme 28: Synthesis of cyclohexadiene-fused 1-(N-benzyl-N-methyl)amino-γ-phosphinolactams from aryl-N,N’-dibe...
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Scheme 29: Synthesis of bis(cyclohexadiene-fused γ-phosphinolactam)s from bis(diphenyl-N-benzylphosphinamide)s....
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Scheme 30: Synthesis of bis(hydroxymethyl-derived cyclohexadiene-fused γ-phosphinolactam)s from tetramethylene...
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Scheme 31: Synthesis of 2-aryl/dimethylamino-1-ethoxy-2-hydrobenzo[c][1,2]azaphosphol-3-one 1-oxides from ethy...
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Scheme 32: Synthesis of ethyl 2-ethoxy-1,2-azaphospholidine-4-carboxylate 2-oxides from ethyl 2-((chloro(ethox...
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Scheme 33: Synthesis of (1S,3R)-2-(tert-butyldiphenylsilyl)-3-methyl-1-phenyl-2,3-dihydrobenzo[c][1,2]azaphosp...
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Scheme 34: Synthesis of 2,3,3a,9a-tetrahydro-4H-1,2-azaphospholo[5,4-b]chromen-4-one (215) from 3-(phenylamino...
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Scheme 35: Synthesis of quinoline-fused 1,2-azaphospholine 2-oxides from 2-azidoquinoline-3-carbaldehydes and ...
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Scheme 36: Synthesis of 1-hydro-1,2-azaphosphol-5-one 2-oxide from cyanoacetohydrazide with phosphonic acid an...
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Scheme 37: Synthesis of chromene-fused 5-oxo-1,2-azaphospolidine 2-oxides.
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Scheme 38: Synthesis of (R)-1-phenyl-2-((R)-1-phenylethyl)-2-hydrobenzo[c][1,2]azaphosphol-3-one 1-oxide (239)...
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Scheme 39: Synthesis of dihydro[1,2]azaphosphole 1-oxides from aryl/vinyl-N-phenylphosphonamidates and aryl-N-...
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Scheme 40: Synthesis of 1,3-dihydro-[1,2]azaphospholo[5,4-b]pyridine 2-oxides.
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