Volume No. 18
2022
Pages 1 - 1771
Table of Contents |
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| 124 | Full Research Paper |
| 17 | Review |
| 31 | Letter |
| 5 | Perspective |
| 1 | Commentary |
| 7 | Editorial |
- Full Research Paper
- Published 03 Jan 2022
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Scheme 1: Synthesis of SMC stapled axin CBD peptides. Reaction conditions: (a) Pd2(dba)3, sSPhos, KF, DME/EtO...
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Scheme 2: Overview of the different cross-linkages obtained by intramolecular SMC. A) General structure of SM...
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Figure 1: Analysis of the secondary structure by circular dichroism: CD spectra of both isomers of stapled pe...
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Figure 2: In vitro binding affinities to β-catenin determined by competitive fluorescence polarisation assays....
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Figure 3: Cleavage sites of Proteinase K digestion indicated by a red arrow.
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Figure 4: Principal component analysis (PCA) of the macrocycle’s non-hydrogen atoms in the two isomers of P5....
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Figure 5: Molecular modelling of the conformational preferences of the SMC stapled peptides P5 (with cis or t...
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Figure 1: Initially assigned structures for patchoulol by Treibs (1) and by Büchi (2). Structures of patchoul...
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Scheme 1: Biosynthesis of patchoulol (part I). A) Cyclisation mechanism from FPP to 3 as suggested by Croteau...
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Scheme 2: Biosynthesis of patchoulol (part II). A) Cyclisation mechanism from FPP to 3 as suggested by Akhila...
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Scheme 3: Biosynthesis of patchoulol (part III). A) Cyclisation mechanism from FPP to 3 as suggested by Faral...
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Figure 2: ORTEP representation of patchoulol (3). Cu Kα, Flack parameter: −0.1(2); P2(true) = 1.000, P3(false...
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Scheme 4: Determination of the absolute configurations of compounds 3 and 12 through stereoselective labellin...
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Scheme 5: Labelling experiments on the biosynthesis of patchoulol (3, part 1). Black dots indicate 13C-labell...
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Scheme 6: Labelling experiments on the biosynthesis of patchoulol (3, part 2). Black dots indicate 13C-labell...
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Figure 3: Energy profile from DFT calculations (Gibbs energies at 298 K, mPW1PW91/6-311 + G(d,p)//B97D3/6-31G...
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Figure 4: Structure elucidation of (2S,3S,7S,10R)-guaia-1,11-dien-10-ol (17) and structure of its known stere...
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- Published 04 Jan 2022
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Figure 1: Selected examples of natural products and drugs possessing the indane scaffold.
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Scheme 1: Known strategies and conceptual advance of this contribution.
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Figure 2: Selected examples of bioactive spirobarbiturates.
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Figure 3: The screened organocatalysts.
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Scheme 2: Substrate scope of 2-isothiocyanato-1-indanones. The reactions were carried out with 1 (0.12 mmol), ...
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Scheme 3: Substrate scope of barbiturate-based olefins. The reactions were carried out with 1a (0.12 mmol), 2...
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Figure 4: X-ray crystal structure of 3ae (displacement ellipsoids are drawn at the 50% probability level).
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Scheme 4: Gram-scale synthesis of 3ah.
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Scheme 5: Further transformation of 3ah.
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Scheme 6: One-pot three-component reaction.
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Scheme 7: Proposed reaction mechanism.
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- Review
- Published 04 Jan 2022
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Scheme 1: Starch-immobilized ruthenium trichloride-catalyzed cyanation of tertiary amines.
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Scheme 2: Proposed mechanism for the cyanation of tertiary amines using starch-immobilized ruthenium trichlor...
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Scheme 3: Cyanation of tertiary amines using heterogeneous Ru/C catalyst.
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Scheme 4: Proposed mechanism for cyanation of tertiary amines using a heterogeneous Ru/C catalyst.
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Scheme 5: Ruthenium-carbamato complex-catalyzed oxidative cyanation of tertiary amines.
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Scheme 6: Cyanation of tertiary amines using immobilized MCM-41-2N-RuCl3 as the catalyst.
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Scheme 7: Cyanation of tertiary amines using RuCl3·nH2O as the catalyst and molecular oxygen as oxidant.
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Scheme 8: RuCl3-catalyzed cyanation of tertiary amines using NaCN/HCN and H2O2 as oxidant.
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Scheme 9: Proposed mechanism for the ruthenium-catalyzed oxidative cyanation using H2O2.
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Scheme 10: Proposed mechanism for the ruthenium-catalyzed aerobic oxidative cyanation.
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Scheme 11: RuCl3-catalyzed oxidative cyanation of tertiary amines using acetone cyanohydrin as the cyanating a...
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Scheme 12: Cyanation of indoles using K4[Fe(CN)6] as cyano source and Ru(III)-exchanged NaY zeolite (RuY) as c...
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Scheme 13: Cyanation of arenes and heteroarenes using a ruthenium(II) catalyst and N-cyano-N-phenyl-p-toluenes...
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Scheme 14: Proposed mechanism for the cyanation of arenes and heteroarenes using ruthenium(II) as catalyst and...
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Scheme 15: Synthesis of N-(2-cyanoaryl)-7-azaindoles.
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Figure 1: Structure of the TiO2-immobilized ruthenium polyazine complex.
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Scheme 16: Visible-light-induced oxidative cyanation of aza-Baylis–Hillman adducts.
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Scheme 17: Synthesis of 1° alkyl nitriles using [Ru(bpy)3](PF6)2 as the photocatalyst.
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Scheme 18: Synthesis of 2° and 3° alkyl nitriles using [Ru(bpy)3](PF6)2 as the photocatalyst.
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Scheme 19: Photoredox cross coupling reaction.
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Scheme 20: Synthesis of α-amino nitriles from amines via a one-pot strategy.
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Scheme 21: Proposed mechanistic pathway for the cyanation of the aldimine intermediate.
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Scheme 22: Strecker-type functionalization of N-aryl-substituted tetrahydroisoquinolines under flow conditions....
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Scheme 23: One-pot synthesis of α-aminonitriles using RuCl3 as catalyst.
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Scheme 24: Synthesis of alkyl nitriles using (Ru(TMHD)3) as the catalyst.
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Scheme 25: Synthesis of cyanated isoxazolines from alkenyl oximes catalyzed by [RuCl2(p-cymene)]2 in the prese...
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Scheme 26: Proposed mechanism for the synthesis of cyanated isoxazolines from alkenyl oximes.
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Scheme 27: Oxidative cyanation of differently substituted alcohols.
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- Review
- Published 05 Jan 2022
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Figure 1: Naphthoquinones are commonly used in organic synthesis.
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Figure 2: Some important natural and synthetic naphthoquinones.
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Scheme 1: Synthetic studies of BNQs and reactions with amines.
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Scheme 2: Methods described for the synthesis of β-NQS.
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Figure 3: Drugs detected using β-NQSNa.
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Scheme 3: Reactions between β-NQS and amines.
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Scheme 4: Isomerization of 4-arylamino-1,2-naphthoquinones.
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Scheme 5: Synthesis of unsymmetrical 2-amino-4-imino compounds.
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Scheme 6: Synthesis of bis(isoxazolyl)naphthoquinones from β-NQS.
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Scheme 7: The reaction of β-NQS with 30 followed by cycle condensation.
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Scheme 8: Synthesis of 4-(2-amino-5-selenothiazoles)-1,2-naphthoquinones.
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Scheme 9: Synthesis of amino- and phenoxy-1,2-naphthoquinones.
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Scheme 10: Synthesis of 4-semicarbazide-1,2-naphthoquinone.
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Scheme 11: Reactions of 4-azido-1,2-naphthoquinone.
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Figure 4: Modifications that can be easily carried out from the products of β-NQS 8.
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Scheme 12: Derivatives of 1,2-naphthoquinones obtained from β-NQS.
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Scheme 13: Oximes as well as 4-amino- and 4-phenoxy-1,2-naphthoquinone as potential anti-inflammatory agents.
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Scheme 14: Synthesis of triazoles from β-NQS.
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Scheme 15: Synthesis of naphtho[1,2-d]oxazoles from β-NQS.
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Scheme 16: A) Arylation and vinylation of β-NQS catalyzed by Ni(II) salts. B) Transformation of the 1,2-dicarb...
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Scheme 17: Benzo[a]carbazole and benzo[c]carbazoles fused with 1,2-naphthoquinone.
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Scheme 18: Synthesis of 1,2-naphthoquinones having a C=C bond from β-NQS. Method A: NaOH, EtOH/H2O, 40 °C, 2 h...
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Scheme 19: C=C bond formation from β-NQS and substituted acetonitriles.
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- Full Research Paper
- Published 05 Jan 2022
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Figure 1: Oxazoline-containing bioactive natural products.
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Scheme 1: Synthetic methods of oxazoline derivatives.
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Scheme 2: Scopes of aziridines and diazo esters.
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Scheme 3: Proposed reaction mechanism.
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Scheme 4: Direction of tautomerization.
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- Published 06 Jan 2022
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Figure 1: Examples of natural products containing β-amino acids.
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Scheme 1: Synthesis of cyclic β-amino acid 6.
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Scheme 2: Epoxidation of Boc-protected amino ester 4 and hydrolysis of epoxide 7 with HCl(g)–MeOH.
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Scheme 3: Reaction of epoxide 7 with NaHSO4 in methylene chloride/MeOH.
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Figure 2: The X-ray crystal structure of 10.
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Scheme 4: Synthesis of cyclic β-amino acid derivative 8.
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Scheme 5: Suggested mechanism for the reaction of epoxide 7 with NaHSO4.
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Figure 3: Solvent-corrected relative free energy profile at 298.15 K for the reaction mechanism of 14 shown i...
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Figure 4: Solvent-corrected relative free energy profile at 298.15 K for the reaction mechanism of 17 shown i...
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Figure 5: The optimized geometries of the conformers 7a and 7b with selected interatomic distances at the B3L...
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- Published 10 Jan 2022
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Figure 1: Representative pharmaceuticals containing N-acylindole moieties.
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Scheme 1: A) Strategies for the synthesis of N-acylindoles; B) thioester as dicarbonylation reagent; C) recen...
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Scheme 2: Reactions of thioesters and indoles. Reaction conditions: 1 (0.2 mmol, 1.0 equiv), 2 (0.6 mmol, 3.0...
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Scheme 3: Gram-scale experiment.
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Scheme 4: Control experiments.
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Scheme 5: Proposed mechanism.
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- Published 11 Jan 2022
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Figure 1: Structure of AZT and representative related bicyclic nucleosides.
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Scheme 1: Retrosynthetic routes for the synthesis of (5′R)-3′-azido-3′-deoxy-2′-O,5′-C-bridged-β-ᴅ-homoarabin...
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Scheme 2: Synthesis of 3′-azido-3′-deoxy-β-ᴅ-allofuranosylthymine (14a) and -uracil (14b).
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Scheme 3: Biocatalytic acetylation of the primary hydroxy group of nucleosides 14a,b.
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Scheme 4: Synthesis of (5'R)-3′-azido-3′-deoxy-2′-O,5′-C-bridged-β-ᴅ-homoarabinofuranosyl nucleosides 9a,b.
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Scheme 5: Chemical synthesis of nucleosides 9a,b starting from diacetone ᴅ-glucofuranose.
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Figure 2: Structure elucidation of (5′R)-3′-azido-3′-deoxy-2′-O,5′-C-bridged-β-ᴅ-homoarabinofuranosylthymine (...
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Scheme 6: a) Plausible mechanism for the synthesis of (5′R)-3′-azido-3′-deoxy-2′-O,5′-C-bridged-β-ᴅ-homoarabi...
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- Published 12 Jan 2022
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Figure 1: Examples of amino-functionalized 1,2-oxazole derivatives I–VIII.
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Scheme 1: Conversion of cyclic amino acids to 1,2-oxazole derivatives.
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Scheme 2: Plausible mechanisms for the formation of 1,2-oxazoles 4a–h and VII from β-enamino ketoesters 3a–h ...
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Figure 2: (a) 1H NMR (italics), 13C NMR (normal), and 15N NMR (bold) chemical shifts (ppm) of compound 3a in ...
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Scheme 3: Synthesis of compound 15N-1,2-oxazole 5. The coupling constants of JHN and JCN from 15N2 are indica...
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Figure 3: Stacked chromatogram view of pairs of enantiomers with area, %: (R)-4b, ee 100% (tR = 10.1 min) and...
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Figure 4: (a) Structure of 4b with syn- and anti-conformers; (b) superimposed 1H NMR and 1D gradient NOE spec...
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Scheme 4: Synthesis of 2-[4-(methoxycarbonyl)-1,2-oxazol-5-yl]cycloaminyl-1-ium trifluoroacetates 6a,b.
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Figure 5: ORTEP diagram of the asymmetric unit consisting of two cations 6b(A) and 6b(B) and triflate anions.
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- Published 13 Jan 2022
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Figure 1: Structures of tenacibactins K–M (1–3).
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Figure 2: Key 2D-NMR correlations for 1–3.
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Figure 3: (a) Partial 1H NMR spectra of 1 at 25 and 50 °C in DMSO-d6; (b) magnified HMBC spectrum of 1 at 25 ...
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Figure 4: MS/MS spectrum of 1 acquired on a quadrupole time-of-flight mass spectrometer in the negative ion m...
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Scheme 1: MS/MS fragmentation pathway for compound 1.
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- Published 17 Jan 2022
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Scheme 1: Organic reactions where the breaking of a C–X bond involves the formation of a high energy ion-pair...
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Scheme 2: The chemical structures for the 1-adamantyl substrate, 2-adamantyl substrate, and the S-methyldiben...
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Figure 1: The SN2 reaction plot of log (k/ko) vs (1.26 NT + 0.65 YCl) for the solvolyses of benzesulfonyl chl...
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Figure 2: The SN2 reaction plot of log (k/ko) vs (1.35 NT + 0.70 YCl) for the solvolyses of 2-thiophenesulfon...
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- Full Research Paper
- Published 25 Jan 2022
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Figure 1: FTIR spectra of (a) the Ni–chitosan NPs and (b) bare chitosan.
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Figure 2: PXRD data for the Ni–chitosan NPs.
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Figure 3: TEM (a and b) and SEM images (c and d) of the Ni–chitosan NPs.
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Figure 4: EDX spectrum of the Ni–chitosan NPs.
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Figure 5: Synthesis of dialkyl 1,4-dihydropyridine-2,3-dicarboxylate derivatives.
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Figure 6: ORTEP representation of product 4a (CCDC 1949329).
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Scheme 1: A plausible mechanistic route for the synthesis of C5–C6-unsubstituted 1,4-DHP derivatives using th...
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Figure 7: Recycling experiment of the Ni–chitosan nanocatalyst.
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- Published 26 Jan 2022
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Figure 1: Paullone related indolobenzazepinone isomers. 7,12-Dihydroindolo[3,2-d][1]benzazepin-6(5H)-one or p...
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Scheme 1: Investigated retrosynthetic pathways to scaffold C.
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Scheme 2: Attempted synthesis of scaffold C by route (a).
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Scheme 3: Attempted synthesis of C by route (b).
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Scheme 4: Attempted synthesis of N-benzylated indole-2-acetic acid.
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Scheme 5: Attempt to obtain open-chain precursor N-(2-bromophenyl)-2-(1H-indol-2-yl)acetamide.
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Scheme 6: Synthesis of scaffold C and analogues by route (c).
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Figure 2: ORTEP view of 1a with thermal ellipsoids drawn at the 50% probability level.
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Figure 3: ORTEP view of 3a with thermal ellipsoids drawn at the 50% probability level.
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Scheme 7: Attempted Ullmann cross-coupling of 23 with o-bromo-nitrobenzene.
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- Published 27 Jan 2022
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Scheme 1: Radical chain mechanism for a photo-induced C–H chlorination reaction.
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Figure 1: Components for photoflow setup: (a) MiChS LX-1 reactor and (b) MiChS LED-s (365 ± 5 nm, 60–600 W).
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Scheme 2: Model reaction: photoflow C–H chlorination of ethylene carbonate (1) to chloroethylene carbonate (2...
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Figure 2: Photoflow setup for the C–H chlorination of ethylene carbonate (1).
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- Published 31 Jan 2022
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Scheme 1: Molecular structures of the parent phosphopeptide 1 and its pyrrole-conjugated analogs 2–14.
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Figure 1: Cell viability of HeLa cells treated with 200 μM of each compound for 24 h.
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Figure 2: Cell viability of HeLa cells treated with 20 μM, 50 μM, 100 μM, 200 μM and 400 μM of 1, 4a and 6b f...
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Figure 3: A) TEM images of 1 before and after addition of ALP (0.5 U/mL) in PBS buffer (pH 7.4). Scale bar is...
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- Published 03 Feb 2022
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Figure 1: Model of the catalyst action.
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Figure 2: Catalysts screened.
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Scheme 1: Screening of different N-protecting groups. Reaction conditions: 0.2 M solution of 1 (1 equiv), 2 (...
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Scheme 2: Scope of the reaction (the relative configuration of the major diastereoisomer is depicted). Reacti...
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Scheme 3: Comparison reactions of E- and Z-isomers (the relative configurations of the major diastereoisomers...
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- Published 04 Feb 2022
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Figure 1: Naturally occurring HDAC inhibitors.
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Figure 2: Naturally occurring HDAC inhibitors with different zinc-binding motifs.
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Scheme 1: Planned syntheses of Cyl-1 derivatives.
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Scheme 2: Cyl-1 derivatives via peptide Claisen rearrangement.
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Scheme 3: Synthesis of tetrapeptide allyl esters 8.
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Scheme 4: Synthesis and late stage modifications of Cyl derivatives.
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- Published 07 Feb 2022
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Scheme 1: Examples of mechanochemical reactions using NFSI.
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Scheme 2: Mechanochemical fluorination of arenes 1 with NFSI. (a) Product distributions and reaction conditio...
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Figure 1: Time-resolved 2D plots of the mechanochemical reaction of: (a) 1c (0.59 mmol), NFSI (1.0 equiv), an...
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Scheme 3: (a–f) Reactions of substrates 3 with NFSI. Reaction conditions: Substrates 3 (0.734 mmol) were mill...
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Scheme 4: Regioselective C-3 mechanochemical amidation of 5 with NFSI.
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- Published 10 Feb 2022
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Figure 1: Selected examples of: a) calix[4]arene-; b) resorcin[4]arene-; c) calix[6]arene-gold(I) macrocyclic...
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Scheme 1: i) NH2NH2∙H2O, Pd/C in EtOH, 80 °C (quant.); ii) diphenylphosphinobenzoic acid, EDC∙HCl, DMAP (cat....
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Figure 2: Stacked-plot, mid-field expanded region of the 1H NMR spectrum (400 MHz, 298 K) of A(AuCl)2, B(AuCl)...
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Figure 3: Stacked plot 1H NMR (tetrachloroethane-d2) of A(AuCl)2 at variable temperature.
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Scheme 2: Synthesis of the monomeric gold catalyst analogues A’,B’,C’(AuCl). Conditions: i) diphenylphosphino...
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Figure 1: Chemical structures of compounds 1–17 from W. nutans.
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Figure 2: The key correlations observed in the 1H-1H COSY (bold bonds), HMBC (blue) correlations of 1 (record...
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Figure 3: The key correlations observed in the 1H-1H COSY (bold bonds), HMBC (blue), ROESY (red) of 1 (record...
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Figure 1: Chemical structures and reported activities of viral (A), human neuraminidases (B) and Trypanosoma ...
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Figure 2: Design and synthesis of potential neuraminidase and trans-sialidase inhibitors exploiting a moiety ...
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Figure 3: TcTS and neuraminidase hydrolase activity (A) as well as TcTS transferase activity (B) in the prese...
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Figure 4: TcTS and neuraminidase inhibition by 1,2,3-triazole-linked sialic acid derivatives 3a–h (1 mM) usin...
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Figure 5: Crystal structure of TcTS (PDB code 1MS1 – coloured red) (A) and neuraminidase (PDB code 2VK6 – col...
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- Published 21 Feb 2022
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Scheme 1: Catalytic asymmetric nitroso aldol reaction.
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Scheme 2: Variation of the amide moiety of malonamates. General conditions: 1 (0.20 mmol), 2a (0.24 mmol), 3a...
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Figure 1: ORTEP diagram drawn with 30% ellipsoid probability for non-H atoms of the crystal structure of chir...
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Scheme 3: Variation of ester moiety of malonamates and nitrosoarenes. General conditions: 1 (0.20 mmol), 2a (...
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Scheme 4: Synthetic transformation.
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Figure 2: Proposed transition state for the nitroso aldol reaction.
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Scheme 1: Classical amine purification.
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Scheme 2: Principle of out-of equilibrium machinery using TCA (a) and our application to amines purification ...
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Scheme 3: Application of the TCA purification from a crude reaction mixture.
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Scheme 1: Methods for accessing 1,3,4-oxadiazoles.
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Scheme 2: Synthesis of acyl hydrazones 1a–j.
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Scheme 3: Iodine-mediated cyclisation of hydrazones 1a–j yielding oxadiazoles 2a–j. Reaction conditions: 1a–j...
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Scheme 4: Synthesis of complex oxadiazoles.
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Scheme 5: Continuous flow scale-up reaction with in-line quench and extraction.
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Scheme 6: Continuous flow setup equipped with in-line extraction and purification.
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- Published 01 Mar 2022
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Scheme 1: Chemical structures of [1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine (a), [1,2,4]triazolo[1,5-b][1,2,4,5...
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Scheme 2: Synthesis of [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines 3a–k.
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Figure 1: X-ray structure of N-(6-(4-bromo-3,5-dimethylpyrazol-1-yl)-1,2,4,5-tetrazin-3-yl)benzamide.
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Scheme 3: Reactions of triazolo[1,5-b][1,2,4,5]tetrazines 3a,j with N- and O-nucleophiles.
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Scheme 4: Reactions of triazolo[1,5-b][1,2,4,5]tetrazines 3a,j with C-nucleophiles.
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Scheme 5: Reactions of 6-(3,5-dimethyl-1H-pyrazol-1-yl)-3-methyl-[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine (10a...
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Scheme 1: Previously reported metal-catalyzed reactions of heterobicyclic alkenes and applications towards th...
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Scheme 2: Iridium-catalyzed hydroacylation of C1-substituted OBDs 13a–k with salicylaldehyde 14.
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Scheme 3: Competition reaction of different C1-substituted OBDs.
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Figure 1: Potential energy profile of the PCM solvation model for the hydrometalation/reductive elimination p...
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Figure 2: Potential energy profile of the PCM solvation model for the carbometalation/reductive elimination p...
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Figure 3: Potential energy profile of the PCM solvation model for the endo hydrometalation/reductive eliminat...
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Figure 4: Potential energy profile of the PCM solvation model for the Ir/diene-catalyzed hydroacylation of Me...
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- Published 03 Mar 2022
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Scheme 1: One pot Sonogashira coupling of aryl iodides with arylynols in the presence of iron(III) chloride h...
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Scheme 2: The iron-catalyzed Sonogashira coupling of aryl iodides with terminal acetylenes in water under aer...
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Scheme 3: Sonogashira coupling of aryl halides and phenylacetylene in the presence of iron nanoparticles.
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Scheme 4: Sonogashira coupling catalyzed by a silica-supported heterogeneous Fe(III) catalyst.
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Scheme 5: Suggested catalytic cycle for the Sonogashira coupling using a silica-supported heterogeneous Fe(II...
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Scheme 6: Chemoselective iron-catalyzed cross coupling of 4-bromo-1-cyclohexen-1-yltrifluromethane sulfonate ...
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Scheme 7: Fe-catalyzed Sonogashira coupling between terminal alkynes and aryl iodides.
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Scheme 8: Iron-catalyzed domino Sonogashira coupling and hydroalkoxylation.
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Scheme 9: Sonogashira coupling of aryl halides and phenylacetylene in the presence of Fe(III) acetylacetonate...
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Scheme 10: Sonogashira coupling of aryl iodides and alkynes with Fe(acac)3/2,2-bipyridine catalyst.
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Scheme 11: Sonogashira cross-coupling of terminal alkynes with aryl iodides in the presence of Fe powder/ PPh3...
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Scheme 12: α-Fe2O3 nanoparticles-catalyzed coupling of phenylacetylene with aryl iodides.
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Scheme 13: Sonogashira cross-coupling reaction between phenylacetylene and 4-substituted iodobenzenes catalyze...
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Scheme 14: One-pot synthesis of 2-arylbenzo[b]furans via tandem Sonogashira coupling–cyclization protocol.
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Scheme 15: Suggested mechanism of the Fe(III) catalyzed coupling of o-iodophenol with acetylene derivatives.
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Scheme 16: Fe3O4@SiO2/Schiff base/Fe(II)-catalyzed Sonogashira–Hagihara coupling reaction.
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Scheme 17: Sonogashira coupling using the Fe(II)(bdmd) catalyst in DMF/1,4-dioxane.
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Scheme 18: Synthesis of 7-azaindoles using Fe(acac)3 as catalyst.
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Scheme 19: Plausible mechanistic pathway for the synthesis of 7-azaindoles.
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Scheme 20: Synthesis of Co@imine-POP catalyst.
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Scheme 21: Sonogashira coupling of various arylhalides and phenylacetylene in the presence of Co@imine-POP cat...
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Scheme 22: Sonogashira coupling of aryl halides and phenylacetylene using Co-DMM@MNPs/chitosan.
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Scheme 23: Sonogashira cross-coupling of aryl halides with terminal acetylenes in the presence of Co-NHC@MWCNT...
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Scheme 24: Sonogashira cross-coupling of aryl halides with terminal acetylenes in the presence of Co nanoparti...
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Scheme 25: Sonogashira coupling reaction of aryl halides with phenylacetylene in the presence of Co nanopartic...
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Scheme 26: PdCoNPs-3DG nanocomposite-catalyzed Sonogashira cross coupling of aryl halide and terminal alkynes.
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Scheme 27: Sonogashira cross-coupling of aryl halides and phenylacetylene in the presence of graphene-supporte...
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Scheme 28: Sonogashira cross-coupling with Pd/Co ANP-PPI-graphene.
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Scheme 29: Pd-Co-1(H)-catalyzed Sonogashira coupling reaction.
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Scheme 30: The coupling of aryl halides with terminal alkynes using cobalt hollow nanospheres as catalyst.
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Scheme 31: A plausible mechanism for the cobalt-catalyzed Sonogashira coupling reaction.
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Scheme 32: Sonogashira cross-coupling reaction of arylhalides with phenylacetylene catalyzed by Fe3O4@PEG/Cu-C...
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Scheme 33: Plausible mechanism of Sonogashira cross-coupling reaction catalyzed by Fe3O4@PEG/Cu-Co.
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Scheme 34: Sonogashira coupling reaction of para-substituted bromobenzenes with phenylacetylene in the presenc...
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Scheme 35: Possible mechanism for the visible light-assisted cobalt complex-catalyzed Sonogashira coupling. (R...
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Scheme 36: Sonogashira cross-coupling of aryl halides and phenylacetylene using cobalt as additive.
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Scheme 37: Plausible mechanism of Sonogashira cross-coupling reaction over [LaPd*]. (Reproduced with permissio...
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Figure 1: Some bioactive 3,4-dihydroquinazolines and 4H-3,1-benzothiazines.
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Scheme 1: Representative preperation of 3,4-dihydroquinazolines and 4H-3,1-benzothiazines.
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Scheme 2: Preparation of 3,4-dihydroquinazoline 8a.
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Scheme 3: Preparation of 3,4-dihydroquinazolines 8.
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Scheme 4: Preparation of 4H-3,1-benzothiazines 11.
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- Published 08 Mar 2022
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Scheme 1: SEAr-based, CAr–C bond-forming cyclization or annulation of: (A) substituted arenes/heteroarenes an...
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Scheme 2: Indole C3 regioselective intramolecular alkylation of indolyl allyl carbonates.
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Scheme 3: Indole C3 regioselective Michael-type cyclization in the total synthesis of (−)-indolactam V.
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Scheme 4: Synthesis of azepino[4,3,2-cd]indoles via indole C3 regioselective aza-Michael addition/cyclization...
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Scheme 5: Indole C3 regioselective Pictet−Spengler reaction of 2-(1H-indol-4-yl)ethanamines.
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Scheme 6: Indole C3 regioselective hydroindolation of cis-β-(α′,α′-dimethyl)-4′-methindolylstyrenes.
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Scheme 7: Indole C3 regioselective cyclization leading to the formation of polycyclic azepino[5,4,3-cd]indole...
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Scheme 8: Synthesis of azepino[3,4,5-cd]indoles via iridium-catalyzed asymmetric [4 + 3] cycloaddition of rac...
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Scheme 9: Aldimine condensation/1,6-hydride transfer/Mannich-type cyclization cascade of indole-derived pheny...
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Scheme 10: Indole C5 regioselective intramolecular FC acylation of 4-substituted indoles.
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Scheme 11: Catalyst-dependent regioselectivity switching in the cyclization of ethyl 2-diazo-4-(4-indolyl)-3-o...
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Scheme 12: Indole C5 regioselective cyclization of α-carbonyl sulfoxonium ylides.
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Scheme 13: Indole C5 regioselective cyclization of an indole-tethered donor–acceptor cyclopropane.
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Scheme 14: Indole C5 regioselective epoxide–arene cyclization.
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